![]() ![]() It has been reported the senescence-associated secretory phenotype is promoted by excess body fat associated with increased pro-inflammatory adipokines and cytokines, such as IL-6 and IL-8, alongside cytokines such as monocyte chemoattractant protein-1 (MCP-1), IFNγ, and TNFα (Christiansen et al. The deleterious effects of ageing on immune function are linked to dysregulation of cytokines which are responsible for the promotion of the pro-ageing senescence-associated secretory phenotype (Coppé et al. 2014) while intracellular pro-inflammatory cytokines (including interferon gamma and TNFα) are seen to be elevated in T cells of older vs young participants (Zanni et al. Similarly, interleukin (IL)-6 is elevated with increasing age (Bruunsgaard et al. Indeed, tumour necrosis factor alpha (TNFα) is greater in 80-year-olds relative to younger individuals and greater again in centenarians. The 'inflamm-ageing' hypothesis suggests that chronic ageing is associated with increased reactive oxygen species and increased basal pro-inflammatory state (Franceschi et al. Circulating cytokine dysregulation is well recognised as a consequence of biological ageing (Alvarez-Rodriguez et al. Human ageing involves a loss of function of multiple physiological systems, including the cardiovascular system, respiratory system, musculoskeletal system, and immuno-senescence (Rebelo-Marques et al. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest. As lower EGF has previously been associated with longevity in C. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. Older aerobically trained men have greater serum EGF than younger aerobically trained men. Following SIT, older men decreased EGF to 100 (12) pg mL −1 which was similar to that of young men who did not undergo training ( p = 0.113, Cohen's d = 1.07). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline. Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819 MCP-1, p = 0.248 VEGF, p = 0.264). Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group. Nine older men and eleven younger men comprised the younger group. ![]() A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men. The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |